Gerard Piqué views Tuesday night's Manchester derby as the first of three consecutive cup finals for the Reserves.
The table-topping Reds currently lead Middlesbrough by five points and Aston Villa - who have two games in hand - by six points with three league games remaining.
United face City in their final home game before tricky trips to Liverpool and title rivals Villa in an intriguing climax to the campaign.
"We have just a few matches left and every match is like a final," Piqué told MUTV. "If we win all the games we will have won the league so it depends on us."
"We have three of the most difficult matches left, because it's City at home but the last two games are away at Villa and Liverpool.
"We'll have to fight to win the games, but we have the team to do it and to win the league."
Piqué will be partnered in central defence against City by Jonny Evans, who has returned to the starting line-up after recovering from a groin injury.
The Irish defender made a substitute cameo against West Brom last week, and impressed boss Rene Meulensteen sufficiently to merit his full recall for the Reds' final home game of the season.
"I was very impressed with the way Jonny came back in the team," Rene told ManUtd.com after the game. "He was very composed and did exactly what I wanted."
Evans replaces Ryan Shawcross in the only change to the side that beat West Brom.
Luke Steele continues in goal with Evans, Piqué, Phil Marsh and Danny Rose in defence.
Darron Gibson and Ritchie Jones reprise their partnership in the centre of midfield, while Markus Neumayr and Jamie Mullan occupy the flanks.
Fraizer Campbell partners Giuseppe Rossi upfront as United chase the goals to edge them closer to retaining the FAPRL title.