Man Utd v Liverpool
Rafael Benitez takes his Liverpool side to Old Trafford still looking for his first win against the Red Devils since taking charge in the summer of 2004.
The Reds boss may well have seen his team beat Alex Ferguson's men on the way to FA Cup glory in 2006 but in the league there have been a string of disappointments.
In seven matches we have lost six and drawn one, scoring just one goal in the process.
It's hardly inspiring stuff, but with Liverpool in magnificent form of late, the prospect of our 50th win against United in what will be the 150th league meeting between the sides, looks ever more possible.
The Travelling Kop will no doubt be out in force hopeful of securing our first win on enemy soil since Danny Murphy's penalty gave us a 1-0 victory back in April 2004.
One thing's for sure, with United locked in a tussle for the title and Everton breathing down our necks for fourth - neither side can afford to lose.