Hull defender Michael Dawson has been ruled out for up to four weeks with a hamstring injury sustained in last week's 1-1 draw at Bristol City.
Boss Steve Bruce is without midfielders Robert Snodgrass and David Meyler (both knee), but top scorer Abel Hernandez could return after being rested.
Derby midfielder Bradley Johnson misses the match through suspension after picking up five yellow cards.
Jeff Hendricks or Craig Bryson could step in.
The Tigers have won five of the last six meetings with Derby (L1), enjoying two 2-1 victories over them the last time they met in the league in 2012-13.
Derby have managed just one clean sheet in their last 23 meetings with Hull, with that shutout coming in a 1-0 win at the KC Stadium in January 2012.
Hull City have won seven and lost none of their last 11 Championship matches.
The Tigers have conceded a league-low nine goals so far this season.
After failing to score in his first 11 league appearances for Derby, Andreas Weimann has netted in three of his last four.
Derby have lost just once in their last 12 league games, winning nine (D2).