Derby's George Thorne is suspended for a fifth yellow card this season. Bradley Johnson, who substituted Thorne on Saturday, is the likely replacement.
Tom Ince's ankle injury keeps him out again, although he may be fit to face Nottingham Forest on Friday night.
QPR are without Clint Hill (knee) and Sandro (ankle), with the former expected to be out for a month.
Striker Charlie Austin, a sub in the defeat at Brentford, should start but winger Jamie Mackie (hamstring) is out.
Derby have won just one of their last eight home league games against QPR (D4 L3), though it arrived in the most recent match in February 2014 (1-0).
This will be the first meeting between these two sides since their play-off final meeting in May 2014, in which QPR won 1-0 thanks to a Bobby Zamora goal.
Charlie Austin has scored four goals in just two league appearances against Derby at the iPro Stadium.
Derby County have posted the best passing accuracy rate in the division (80%) this season, while QPR have the third-worst percentage (68%).
The Rams have won seven and lost none of their last nine games in league competition.